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Hypercalciuria following ceftriaxone a fact or myth
Anoush Azarfar1, Mohammad Esmaeeli1, Yalda Ravanshad2
1Department of Pediatric Nephrology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Journal of Renal Injury Prevention
|October 16, 2015
Summary
Ceftriaxone, a common antibiotic, did not significantly increase urinary calcium excretion in children within three days. This study found no difference in calcium excretion rates between children receiving ceftriaxone and those who did not.
Area of Science:
- Pediatric Nephrology
- Pharmacology
- Clinical Research
Background:
- Nephrolithiasis is a prevalent global health issue affecting both pediatric and adult populations.
- Ceftriaxone, a frequently prescribed antibiotic, has been implicated in contributing to renal stone formation and hypercalciuria.
Purpose of the Study:
- To investigate the impact of ceftriaxone on urinary calcium excretion rates in pediatric patients.
- To determine if ceftriaxone administration alters calcium levels in children's urine.
Main Methods:
- A randomized study involving 84 healthy children over 3 months old hospitalized for non-renal conditions.
- Participants were divided into two groups: one receiving ceftriaxone and a control group not receiving antibiotics.
- Urinary calcium excretion was measured as the calcium to creatinine ratio on days 1 and 3 of admission.
Main Results:
- On the first day, mean calcium excretion was similar between groups (0.13 ± 0.06 vs. 0.14 ± 0.02, P=0.1).
- After three days, urinary calcium to creatinine ratio increased in both groups but showed no significant difference (0.27 ± 0.2 vs. 0.26 ± 0.08, P=0.8).
Conclusions:
- Urinary calcium excretion approximately doubles within a short period post-admission, potentially due to conditions like gastroenteritis.
- Ceftriaxone does not appear to uniquely increase urinary calcium excretion compared to other antibiotics within a three-day period in children.
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