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Red Cell Distribution Width Can Predict the Significance of Angiographically Intermediate Coronary Lesions
Sadık Kadri Açıkgöz1, Burak Açar, Selahattin Aydın
1Cardiology Clinic, Turkiye Yuksek Ihtisas Education and Research Hospital, Ankara, Turkey.
Insights
Higher red cell distribution width (RDW) levels are linked to functionally significant intermediate coronary artery lesions. This finding suggests RDW may help identify patients needing further intervention for coronary artery disease.
Area of Science:
- Cardiology
- Hematology
- Diagnostic Medicine
Background:
- Intermediate coronary artery stenosis (40-70%) poses diagnostic challenges.
- Fractional flow reserve (FFR) is a key method for assessing lesion significance.
- Red cell distribution width (RDW) is an indicator of red blood cell heterogeneity.
Purpose of the Study:
- To investigate the association between RDW and the functional significance of intermediate coronary artery lesions.
- To determine if RDW can predict functionally significant stenosis.
Main Methods:
- 246 patients with intermediate coronary stenosis underwent FFR measurement.
- RDW levels were measured using a hematology analyzer.
- Logistic regression analysis was employed to assess associations.
Main Results:
- 62 patients (25.2%) had functionally significant stenosis (FFR <0.75).
- Mean RDW was significantly higher in patients with significant stenosis (14.19% vs. 13.69%, p < 0.001).
- RDW and male gender were independent predictors of significant stenosis (p < 0.001 and p = 0.006, respectively).
Conclusions:
- Increased RDW levels are associated with the functional significance of intermediate coronary artery stenoses.
- RDW may serve as a valuable biomarker in evaluating coronary artery disease severity.
Objective:
In the present study, the association between red cell distribution width (RDW) with functional significance of intermediate coronary artery lesions was investigated.
Materials And Methods:
Two hundred and forty-six consecutive patients, 168 males and 78 females, who underwent fractional flow reserve (FFR) measurement for angiographically intermediate coronary stenosis (40-70% in quantitative coronary analysis) in the left anterior descending coronary artery were enrolled into the study. The functional significance of intermediate coronary artery lesions was determined by FFR measurement. An FFR value <0.75 was defined as functionally significant. Venous blood samples were taken within 48 h before the FFR measurement, and RDW levels were determined by a Coulter LH Series hematology analyzer. Logistic regression analysis was used to examine the association between functional significance in FFR measurement and other variables.
Results:
Of the 246 patients, 62 (25.2%) exhibited significant functional stenosis (FFR <0.75) in the FFR measurement. The mean RDW level was significantly higher in patients with significant stenosis (14.19 ± 0.73 vs. 13.69 ± 0.77, p < 0.001). In stepwise multivariate logistic regression analysis, RDW (OR = 2.489, 95% CI = 1.631-3.799, p < 0.001) and male gender (OR = 2.826, 95% CI = 1.347-5.928, p = 0.006) were independent predictors of significant functional stenosis.
Conclusion:
Increased RDW levels were associated with functional significance of angiographically intermediate coronary artery stenoses.
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