Magnetic resonance technology in human brain science: blueprint for a program based upon morphometry
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Updated: Aug 15, 2026

High-resolution Functional Magnetic Resonance Imaging Methods for Human Midbrain
Published on: May 10, 2012
V S Caviness1, P A Filipek, D N Kennedy
1Pediatric Neurology Service, Massachusetts General Hospital, Boston 02114.
Abstract:
Magnetic resonance images provide a comprehensiveness of analysis of the human brain and levels of resolution never achieved by other modes of pathoanatomic analysis. We review a strategy and technology of MRI-based image analysis which extracts independent measures of brain volumes, shape and position. These parameters are readily correlated with behavioral as well as physiological measures derived from PET and the emerging technology of MRI-based in vivo spectroscopy. A coordinate program which draws upon these methods will have wide applications in human brain science and the study of dynamic properties of human brain disease.
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These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).

