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Updated: Mar 31, 2026

A Novel Inhalation Mask System to Deliver High Concentrations of Nitric Oxide Gas in Spontaneously Breathing Subjects
Published on: May 4, 2021
[Use of laughing gas in dentistry]
Evangelia Liakoni1, Matthias E Liechti
1Abteilung für Klinische Pharmakologie und Toxikologie, Universitätsspital Basel, Basel, Switzerland.
Abstract:
«Laughing gas» (nitrous oxide N2O) has analgesic and sedative properties and is commonly used in dentistry because of its many advantages (ease of use, dose titration, rapid onset, lack of prolonged effects, both analgetic and anxiolytic effects). However, nitrous oxide may cause vitamin B12 deficiency, has abuse liability, and occupational exposure has been associated with infertility, spontaneous abortion, blood dyscrasias, and neurologic deficits. Scavenger systems are recommended to minimize exposure and personnel should be informed about the potential risks.
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