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Updated: Mar 31, 2026

Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring
Published on: December 9, 2010
Appearance of Meningioma on 99mTc-HMPAO SPECT: Correlation with MRI
Zaid Al-Faham1, Mohammad A Kassir2, Daniel Wood2
1Department of Diagnostic Radiology and Molecular Imaging, William Beaumont School of Medicine and Beaumont Health System, Oakland University, Royal Oak, Michigan zaid.al-faham@beaumont.edu.
Abstract:
On brain perfusion SPECT, a primary brain lesion presents as a localized defect that corresponds to the mass lesion. (99m)Tc-HMPAO images generally show a focal defect in the region of abnormality, whether containing necrotic tissue, recurrent tumor, or both. Further characterization with MR imaging is needed to confirm the diagnosis, as demonstrated in this case report.
Insights
Brain perfusion SPECT using 99mTc-HMPAO typically shows defects in primary brain lesions. Magnetic resonance imaging is crucial for confirming diagnoses of necrotic tissue or recurrent tumors.
Area of Science:
- Neurology
- Radiology
- Nuclear Medicine
Background:
- Primary brain lesions can present diagnostic challenges.
- Brain perfusion single-photon emission computed tomography (SPECT) is a key imaging modality.

