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The elucidation of protein function by sequence motif analysis.

T C Hodgman1

  • 1Department of Biochemistry, University of Cambridge, UK.

Computer Applications in the Biosciences : CABIOS
|February 1, 1989
PubMed
Summary

Protein sequence motifs are crucial for understanding protein function. This review covers motif construction, application in function determination, and data interpretation, including 200 examples.

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Area of Science:

  • Bioinformatics
  • Computational Biology
  • Molecular Biology

Background:

  • Protein sequence motifs are increasingly important in biological sequence analysis.
  • Understanding these motifs aids in predicting protein function and evolutionary relationships.

Purpose of the Study:

  • To review current methods for constructing protein sequence motifs.
  • To discuss the application of motifs in determining protein function.
  • To provide guidelines for interpreting motif data.

Main Methods:

  • Literature review of existing methodologies for motif discovery and analysis.
  • Compilation and categorization of prominent protein sequence motifs.
  • Guideline development for data interpretation in motif-based studies.

Main Results:

  • Detailed overview of various protein sequence motif construction techniques.
  • Examples of how motifs are utilized to infer protein function.
  • A comprehensive appendix listing 200 diverse protein sequence motifs.

Conclusions:

  • Protein sequence motifs are powerful tools in bioinformatics and functional genomics.
  • Effective construction and interpretation of motifs are key to advancing protein function prediction.
  • This review serves as a valuable resource for researchers in the field.

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