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Related Concept Videos

Blind Procedures02:07

Blind Procedures

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Ideally, the people who observe and record the children’s behavior are unaware of who was assigned to the experimental or control group, in order to control for experimenter bias. Experimenter bias refers to the possibility that a researcher’s expectations might skew the results of the study. Remember, conducting an experiment requires a lot of planning, and the people involved in the research project have a vested interest in supporting their hypotheses. If the observers knew which...
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The Placebo Effect01:54

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The placebo effect occurs when people's expectations or beliefs influence or determine their experience in a given situation. In other words, simply expecting something to happen can actually make it happen.
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Related Experiment Video

Updated: Mar 31, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
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Migraine Trigger Site Surgery is All Placebo.

Brian E McGeeney1

  • 1Department of Neurology, Boston University School of Medicine, Boston Medical Center, Boston, MA, USA.

Headache
|October 17, 2015
PubMed
Summary

Migraine trigger site surgery, popularized by plastic surgeons, lacks scientific merit. Evidence suggests outcomes are due to placebo effects, not surgical intervention, and it is not recommended.

Area of Science:

  • Neurology
  • Surgical Innovation

Background:

  • Surgical treatments for migraine targeting specific "trigger sites" have gained traction over the past decade.
  • Techniques involve muscle removal or nerve decompression at proposed facial trigger points.

Purpose of the Study:

  • To evaluate the scientific basis and efficacy of migraine trigger site surgery.
  • To determine if surgical intervention offers benefits beyond placebo effects.

Main Methods:

  • Review of existing literature and clinical studies on migraine trigger site surgery.
  • Analysis of the evidence supporting surgical claims versus placebo mechanisms.

Main Results:

  • The scientific basis for migraine trigger site surgery is considered without merit.
Keywords:
migrainemigraine surgeryplacebotrigger site

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  • A single positive placebo-controlled study had significant limitations.
  • Observed outcomes are attributed to natural migraine history and placebo responses.

    • Conclusions:

    • Migraine trigger site surgery should not be performed outside of controlled clinical trials.
    • The American Headache Society advises against this surgical approach due to lack of evidence.