Hexacyclic monoterpenoid indole alkaloids from Rauvolfia verticillata
Yuan Gao1, Ai-Lin Yu2, Gen-Tao Li3
1BioBioPha Co., Ltd., Kunming 650201, People's Republic of China; Department of Chemical Engineering, Yibin University, Yibin 644000, People's Republic of China.
Abstract:
Five new hexacyclic monoterpenoid indole alkaloids, rauvovertine A (1), 17-epi-rauvovertine A (2), rauvovertine B (3), 17-epi-rauvovertine B (4), and rauvovertine C (5) together with 17 known analogues were isolated from the stems of Rauvolfia verticillata. Compounds 1/2 and 3/4 were obtained as C-17 epimeric mixtures due to rapid hemiacetal tautomerism in solution. The structures of 1-5 were established by spectroscopic analysis and with the aid of molecular modeling. The new alkaloids were evaluated for their cytotoxicity in vitro against human tumor HL-60, SMMC-7721, A-549, MCF-7, and SW-480 cell lines.
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