Related Experiment Video
Updated: Mar 31, 2026

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice
Published on: December 21, 2019
Imaging characteristics of pleural tumours
Luca De Paoli1,2, Emilio Quaia1,2, Gabriele Poillucci3,4
1U.C.O. di Radiologia, Dipartimento di Scienze Mediche, Chirurgiche e della Salute, Università degli Studi di Trieste, Azienda Ospedaliero - Universitaria AOUTS, Trieste, Italy.
This study highlights that 11 different pleural neoplasms exist beyond malignant mesothelioma, often misdiagnosed due to overlapping features. Understanding these diverse pleural tumors is crucial for accurate diagnosis.
Area of Science:
- Oncology
- Pathology
- Radiology
- Medical Diagnostics
Background:
- Malignant mesothelioma is the most recognized pleural tumor.
- Several other histological types of pleural neoplasms exist, including mesothelial, mesenchymal, and lymphoproliferative tumors.
- These diverse pleural neoplasms can be misdiagnosed due to overlapping clinical, pathological, and radiological features.
Purpose of the Study:
- To summarize and illustrate the incidence, clinical, pathological, and radiological features of various pleural neoplasms.
- To differentiate between malignant mesothelioma and other less common pleural tumors.
- To emphasize the importance of recognizing diverse pleural tumor types for accurate diagnosis.
Main Methods:
- Review of histological types of pleural neoplasms based on the International Classification of Diseases for Oncology (ICD-O) morphology code.
- Analysis of incidence aspects of these neoplasms.
- Illustration of clinical, pathological, and radiological features for differential diagnosis.
Main Results:
- The International Classification of Diseases for Oncology (ICD-O) categorizes 11 distinct histological types of pleural neoplasms.
- Significant overlap exists in the imaging, clinical presentation, and histopathological findings among different pleural neoplasms.
- Malignant mesothelioma, while common, represents only one type among a broader spectrum of pleural tumors.
Conclusions:
- Accurate diagnosis of pleural neoplasms requires awareness of all 11 histological types classified under the ICD-O.
- The overlapping features of various pleural tumors necessitate a comprehensive diagnostic approach.
- Knowledge of the diverse range of pleural tumors is essential for guiding diagnostic orientation and improving patient outcomes.
Related Concept Videos
Pleural Disorders: Types and Brief Description
Pleura of the Lungs
Pleural Effusion I: Introduction
There are two main types of pleural effusion: transudative and exudative. They are differentiated using Light's...
Pleural Effusion II: Symptoms and Management
A pleural effusion is the abnormal collection of fluid between the parietal and visceral pleura layers of tissue that form the lining of the lungs and chest cavity. It can occur independently or due to surrounding parenchymal diseases, such as infection, malignancy, or inflammatory conditions.
Clinical Manifestations:
Radiological Investigation II: MRI and Ventilation Perfusion Scan
Magnetic Resonance Imaging (MRI) and Ventilation Perfusion Scans are two radiological investigations that offer detailed diagnostic images of the body, particularly lung structures.
MRI
MRI uses magnetic fields and radiofrequency signals to distinguish between normal and abnormal tissues. This technology provides a more detailed diagnostic image than CT scans, enabling it to characterize pulmonary nodules, stage bronchogenic carcinoma, and evaluate inflammatory activity in...
Radiological Investigation III: Pulmonary Angiogram and PET Scan
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...

