Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

T Cell Types and Functions01:24

T Cell Types and Functions

3.3K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
3.3K
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

16.7K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
16.7K
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

620
Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
620
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

669
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
669

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An update on myositis autoantibodies and insights into pathogenesis.

Clinical and experimental rheumatology·2024
Same author

Agreement between local and central anti-synthetase antibodies detection: results from the Classification Criteria of Anti-Synthetase Syndrome project biobank.

Clinical and experimental rheumatology·2024
Same author

The use of ELISA is comparable to immunoprecipitation in the detection of selected myositis-specific autoantibodies in a European population.

Frontiers in immunology·2022
See all related articles

Related Experiment Video

Updated: Mar 31, 2026

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
02:28

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients

Published on: March 1, 2024

1.0K

Early Psoriatic Arthritis.

Neil John McHugh1

  • 1Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath BA2 7AY, UK.

Rheumatic Diseases Clinics of North America
|October 18, 2015
PubMed
Summary

Psoriatic arthritis screening is crucial as delayed diagnosis of skin psoriasis leads to poor outcomes. Early detection through questionnaires and biomarkers may prevent joint damage.

Area of Science:

  • Rheumatology
  • Dermatology
  • Clinical Medicine

Background:

  • Skin psoriasis is a significant risk factor for psoriatic arthritis development.
  • Delayed diagnosis of psoriatic arthritis is linked to adverse long-term health outcomes.
  • Screening questionnaires suggest a substantial number of undiagnosed psoriatic arthritis cases exist.

Purpose of the Study:

  • To review risk factors and diagnostic strategies for psoriatic arthritis in psoriasis patients.
  • To explore the potential of early detection methods to prevent joint damage and disability.

Main Methods:

  • Literature review of recent studies on psoriatic arthritis risk factors and diagnosis.
  • Analysis of the role of screening questionnaires, lifestyle factors, biomarkers, and imaging in early detection.
Keywords:
BiomarkersGenetic screeningPsoriasisPsoriatic arthritis

More Related Videos

Author Spotlight: Enhancing Rheumatoid Arthritis Research Through HR-pQCT Imaging Analysis
06:31

Author Spotlight: Enhancing Rheumatoid Arthritis Research Through HR-pQCT Imaging Analysis

Published on: October 6, 2023

3.5K

Related Experiment Videos

Last Updated: Mar 31, 2026

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
02:28

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients

Published on: March 1, 2024

1.0K
Author Spotlight: Enhancing Rheumatoid Arthritis Research Through HR-pQCT Imaging Analysis
06:31

Author Spotlight: Enhancing Rheumatoid Arthritis Research Through HR-pQCT Imaging Analysis

Published on: October 6, 2023

3.5K
  • Evaluation of current treatment efficacy in preventing joint damage.

    • Main Results:

    • Lifestyle factors, genetic, and soluble biomarkers are under investigation as risk factors.
    • Imaging modalities show promise for detecting early psoriatic arthritis changes.
    • Effective treatments offer the possibility of preventing significant joint damage.

    Conclusions:

    • Accurate and cost-effective screening strategies for psoriatic arthritis require further determination.
    • Early detection and intervention are key to mitigating the long-term impact of psoriatic arthritis.
    • Integrated approaches combining questionnaires, biomarkers, and imaging may enhance diagnostic accuracy.