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Approach to the Patient with a Suspected Cutaneous Adverse Drug Reaction

Laura Swanson1, Roy M Colven1

  • 1Harborview Medical Center, Dermatology Section, Box 359763, 325 9th Avenue, Seattle, WA 98115, USA.

The Medical Clinics of North America
|October 18, 2015
PubMed

Insights

Drug-induced conditions are common but usually mild. Recognizing severe cases of drug reactions is crucial for timely intervention and better patient outcomes, starting with medication withdrawal.

Area of Science:

  • Pharmacology
  • Clinical Medicine
  • Toxicology

Background:

  • Adverse drug reactions (ADRs) are frequent clinical events.
  • Most ADRs present with mild, self-limiting symptoms.
  • A subset of ADRs can be severe, necessitating medical intervention.

Purpose of the Study:

  • To highlight the importance of recognizing severe adverse drug reactions (ADRs).
  • To emphasize the need for prompt identification and management of severe ADRs.
  • To guide clinicians in differentiating mild from severe ADR presentations.

Main Methods:

  • Review of clinical presentations of adverse drug reactions.
  • Analysis of patient outcomes based on ADR severity.
  • Identification of key indicators for severe ADRs.

Main Results:

  • Adverse drug reactions (ADRs) commonly occur and are typically mild.
  • Severe ADRs pose significant risks, requiring prompt clinical attention.
  • Early identification of culprit medications is paramount in managing all ADRs.

Conclusions:

  • Clinicians must be vigilant for signs of severe adverse drug reactions (ADRs).
  • Appropriate triage, work-up, and treatment are essential for severe ADRs.
  • Withdrawal of the offending medication is the critical first step in managing all ADRs.

Keywords:
Drug-induced hypersensitivity syndromeExanthematous eruptionSJS/TENUrticaria

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