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Updated: Mar 31, 2026
Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
Published on: November 20, 2015
Controversies in preterm brain injury
Anna A Penn1, Pierre Gressens2, Bobbi Fleiss2
1Fetal Medicine Institute, Neonatology, Center for Neuroscience Research, Children's National Medical Center, George Washington University School of Medicine, Washington, DC, USA.
Abstract:
In this review, we highlight critical unresolved questions in the etiology and mechanisms causing preterm brain injury. Involvement of neurons, glia, endogenous factors and exogenous exposures is considered. The structural and functional correlates of interrupted development and injury in the premature brain are under active investigation, with the hope that the cellular and molecular mechanisms underlying developmental abnormalities in the human preterm brain can be understood, prevented or repaired.
