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Updated: Mar 31, 2026

09:59
Utilizing pHluorin-tagged Receptors to Monitor Subcellular Localization and Trafficking
Published on: March 16, 2017
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Raman/fluorescence dual-sensing and imaging of intracellular pH distribution
Yue Cao1, Ruo-Can Qian1, Da-Wei Li1
1Key Laboratory for Advanced Materials & Department of Chemistry, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, P. R. China. ytlong@ecust.edu.cn.
Abstract:
Herein, a pH-sensitive probe has been designed based on DNA modified gold nanoparticles (AuNPs) for Raman/fluorescence dual-imaging of the intracellular pH distribution. In the acidic environment of cancer cells, the configuration change of DNA on the probe surface could turn "on" Raman/fluorescence signals simultaneously.

