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HLC/pullulan and pullulan hydrogels: their microstructure, engineering process and biocompatibility.

Xian Li1, Wenjiao Xue2, Yannan Liu3

  • 1College of chemistry & materials science, Northwest University, Taibai North Road 229, Xi'an, Shaanxi 710069, China; Shaanxi Key Laboratory of Degradable Biomedical Materials, Department of Chemical Engineering, Northwest University, Taibai North Road 229, Xi'an, Shaanxi 710069, China.

Materials Science & Engineering. C, Materials for Biological Applications
|October 20, 2015
PubMed
Summary
This summary is machine-generated.

New injectable hydrogels combining pullulan and human-like collagen (HLC) show promise as soft tissue fillers. These HLC/pullulan hydrogels reduce inflammation and improve cell adhesion compared to pullulan alone.

Keywords:
BiodegradationHLC/pullulan hydrogelsNaIO(4)Pullulan hydrogelsSubcutaneous

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Polymer Chemistry

Background:

  • Soft tissue fillers are crucial for addressing medical needs in tissue defect repair.
  • Existing biomaterials often face limitations such as inflammation and poor mechanical properties.

Purpose of the Study:

  • To develop and evaluate novel pullulan and human-like collagen (HLC) based hydrogels for soft tissue filler applications.
  • To investigate the physicochemical properties and in vitro/in vivo efficacy of these HLC/pullulan hydrogels.

Main Methods:

  • Fabrication of pullulan hydrogels and HLC/pullulan hydrogels using sodium periodate (NaIO4) crosslinking.
  • Physicochemical characterization including spectroscopy, microscopy, mechanical testing, and degradation studies.
  • In vitro assessment of cell adhesion and viability, and in vivo subcutaneous filling assays.

Main Results:

  • HLC incorporation significantly enhanced hydrogel properties, overcoming limitations of pure pullulan hydrogels.
  • Confirmed good miscibility and improved mechanical strength of HLC/pullulan hydrogels.
  • Demonstrated reduced inflammation, enhanced cell adhesion, and delayed degradation in HLC/pullulan hydrogels.

Conclusions:

  • HLC/pullulan hydrogels exhibit superior properties and therapeutic potential as effective soft tissue fillers.
  • The developed hydrogels offer a promising solution for tissue defect repair with improved biocompatibility.
  • Further research supports the clinical translation of these advanced biomaterials.