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Resveratrol and Malignancies.

Rodica P Bunaciu1, Andrew Yen1

  • 1Department of Biomedical Sciences, Cornell University, Ithaca, NY, 14853, USA.

Current Pharmacology Reports
|October 20, 2015
PubMed
Summary
This summary is machine-generated.

Resveratrol, a compound found in supplements, may reduce cancer risk by impacting initiation, promotion, and progression. Further research should investigate the effects of typical dietary resveratrol levels, not just high doses used in animal studies.

Keywords:
3,4′,5-Trihydroxy-trans-stilbene5-[(1E)-2-(4-Hydroxyphenyl) ethenyl]-1,3-benzenediolResveratrolStilbenecancerhuman

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Area of Science:

  • Oncology
  • Molecular Biology
  • Nutritional Science

Background:

  • Carcinogenesis is a complex, multi-stage process involving cellular and organismal deviations.
  • Chronic inflammation is a known risk factor contributing to cancer development.
  • Resveratrol is a popular dietary supplement antioxidant used for potential anti-inflammatory and anti-cancer effects.

Purpose of the Study:

  • To explore the role of resveratrol in mitigating the stages of carcinogenesis.
  • To address the discrepancy between high-dose animal study findings and typical human dietary intake of resveratrol.
  • To highlight the potential benefits of studying normal dietary levels of resveratrol.

Main Methods:

  • Review of existing scientific literature on carcinogenesis and resveratrol.
  • Analysis of dose-response relationships in animal models versus human consumption.
  • Identification of research gaps concerning physiological resveratrol concentrations.

Main Results:

  • Animal studies indicate resveratrol can inhibit all three stages of carcinogenesis (initiation, promotion, progression).
  • A significant gap exists between the high doses used in animal research and the lower doses typically consumed by humans.
  • The health benefits of high-dose resveratrol are acknowledged, but effects at normal dietary levels require further investigation.

Conclusions:

  • While high-dose resveratrol shows promise in preclinical models, its efficacy at dietary levels warrants focused research.
  • Understanding resveratrol's impact at physiologically relevant concentrations is crucial for accurate health recommendations.
  • Future research should prioritize investigating the effects of normal dietary resveratrol intake on cancer risk and chronic diseases.