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Cellular dye lasers: lasing thresholds and sensing in a planar resonator.

Matjaž Humar, Malte C Gather, Seok-Hyun Yun

    Optics Express
    |October 20, 2015
    PubMed
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    Researchers developed a simple method to create lasers using biological cells and fluorescent dyes. This technique enables cellular sensing and cytometry, with laser output tunable by cell properties like osmotic pressure.

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    Area of Science:

    • Biophotonics
    • Cellular Engineering
    • Microfluidics

    Background:

    • Biological cell lasers offer potential for biocompatible optical systems.
    • Cellular sensing and cytometry benefit from microfluidic integration.
    • Fluorescent dyes can provide optical gain for laser applications.

    Purpose of the Study:

    • To demonstrate a simple method for creating lasers using biological cells and fluorescent dyes.
    • To explore the use of cells as lensing elements in laser cavities.
    • To investigate the influence of cell properties on laser output modes.

    Main Methods:

    • Utilizing standard fluorescent dyes as gain media, both intracellularly and extracellularly.
    • Employing a planar Fabry-Perot cavity configuration.
    • Analyzing the cell's refractive index and shape as a convex lens.
    • Investigating the effect of osmotic pressure on laser resonance modes.

    Main Results:

    • A flexible method for generating optical gain within or around cells was established.
    • Cells were shown to act as convex lenses, stabilizing laser cavities and suppressing external lasing.
    • Laser resonance modes were demonstrated to be dependent on cell shape, internal structure, and osmotic pressure.

    Conclusions:

    • This method provides a versatile platform for cell-based lasers applicable to all cell types.
    • The cellular lensing effect is crucial for stable laser operation and mode control.
    • Tunable laser output based on cellular physical and structural properties opens new avenues for biosensing.