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Updated: Mar 31, 2026
A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma
Published on: January 5, 2017
Extracranial neurogenic tumors of the head and neck
Otávio Alberto Curioni1, Ricardo Pires de Souza2, Ana Maria da Cunha Mercante3
1Faculdade de Ciências Médicas de Santos, Centro Universitário Lusíada (UNILUS), São Paulo, SP, Brazil; Department of Head and Neck Surgery and Otorhinolaryngology, Hospital Heliópolis, São Paulo, SP, Brazil.
Introduction:
Peripheric nerve tumors typically derive from Schwann cells of the peripheral nerve sheet. Since these tumors are uncommon, they should be considered in preoperative differential diagnosis.
Objective:
To report the experience of a tertiary care department.
Methods:
Forty-two patients with head and neck peripheral neurogenic tumors were retrospectively analyzed and evaluated from 1977 to 2013. The preoperative diagnosis was confirmed by biopsy or imaging study.
Results:
The mean age was 41.7 and 15 patients (36%) were male. The mean size was 5.5cm and 26 (61%) were located laterally in the neck. Most tumors (39.9%) presented as an asymptomatic neck mass. Most (39.9%) were resected through a neck approach. Cranial nerves were the commonest site of origin.
Conclusions:
Extracranial neurogenic tumors presented with a mean size of 5.5cm, were located laterally in the neck, normally had their origin from cranial nerves, and their resection approach is cervical.
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