Regulatory Elements in Vectors for Efficient Generation of Cell Lines Producing Target Proteins
O Maksimenko1, N B Gasanov1, P Georgiev1
1Institute of Gene Biology, Russian Academy of Sciences, Vavilova str. 34/5, 119334, Moscow, Russia.
Acta Naturae
|October 21, 2015
Abstract:
To date, there has been an increasing number of drugs produced in mammalian cell cultures. In order to enhance the expression level and stability of target recombinant proteins in cell cultures, various regulatory elements with poorly studied mechanisms of action are used. In this review, we summarize and discuss the potential mechanisms of action of such regulatory elements.
