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Mechanistic models enable the rational use of in vitro drug-target binding kinetics for better drug effects in

Wilhelmus E A de Witte1, Yin Cheong Wong1, Indira Nederpelt2

  • 1a Division of Pharmacology, Leiden Academic Centre for Drug Research , Leiden University , Einsteinweg 55, 2333 CC Leiden , The Netherlands.

Expert Opinion on Drug Discovery
|October 21, 2015
PubMed
Abstract

Keywords:
PKPD modelingdrug-target binding kineticsendogenous competitionin vitroin vivomechanisticnonspecific bindingpatientsrebindingtarget turnover

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