Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Ethical Issues01:27

Ethical Issues

2.5K
Nurses are essential in patient care, upholding the ethical principles of their profession and effectively navigating ethical dilemmas. Neglecting ethical issues can lead to inadequate patient care, compromised therapeutic relationships, and moral distress among healthcare workers.
Ethical Concerns in Healthcare:
2.5K
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

355
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
355
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

316
In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
316
Heart Failure III: Clinical Manifestations01:26

Heart Failure III: Clinical Manifestations

879
Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
879
Methods of Documentation VI: Case Management Model01:15

Methods of Documentation VI: Case Management Model

1.0K
The case management model is a multidisciplinary approach that involves healthcare professionals from diverse disciplines, such as physicians, nurses, therapists, social workers, and pharmacists, working collaboratively to address the various needs of patients. Each healthcare professional brings unique expertise and perspectives, contributing to a more comprehensive understanding of the patient's condition and tailoring treatment plans accordingly.
For example, a patient with a chronic...
1.0K
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

4.1K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
4.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

DO-HEALTH: Vitamin D3 - Omega-3 - Home exercise - Healthy aging and longevity trial - Design of a multinational clinical trial on healthy aging among European seniors.

Contemporary clinical trials·2020
Same author

Dickkopf-1 Overexpression in vitro Nominates Candidate Blood Biomarkers Relating to Alzheimer's Disease Pathology.

Journal of Alzheimer's disease : JAD·2020
Same author

Precision prevention of Alzheimer's and other dementias: Anticipating future needs in the control of risk factors and implementation of disease-modifying therapies.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2020
Same author

The genetic architecture of human brainstem structures and their involvement in common brain disorders.

Nature communications·2020
Same author

An epigenome-wide association study of Alzheimer's disease blood highlights robust DNA hypermethylation in the HOXB6 gene.

Neurobiology of aging·2020
Same author

Antidepressant Use and Progression of Mild to Moderate Alzheimer's Disease: Results from the European ICTUS Cohort.

Journal of the American Medical Directors Association·2020
Same journal

Chairpersons, Speakers and Contributors.

Nestle Nutrition Institute workshop series·2024
Same journal

Integrating Next-Generation Evidence-Based Medicine Into Clinical Studies on Gut Microbiota Modulation.

Nestle Nutrition Institute workshop series·2024
Same journal

The Art of Chewing: Optimizing Early Life Sensory Exposure to Develop Healthy Eating Behavior.

Nestle Nutrition Institute workshop series·2024
Same journal

What Does Healthy Microbiome Development Look Like? State of the Art and Beyond.

Nestle Nutrition Institute workshop series·2024
Same journal

Strategies to Develop Balanced Dietary Habits: Solving the Dilemma.

Nestle Nutrition Institute workshop series·2024
Same journal

Understanding the Ovarian Clock - Essential Knowledge for Pediatricians.

Nestle Nutrition Institute workshop series·2024
See all related articles

Related Experiment Video

Updated: Mar 31, 2026

Author Spotlight: Assessing Surgical Frailty with Point-of-Care Ultrasound of Quadriceps Muscles
04:00

Author Spotlight: Assessing Surgical Frailty with Point-of-Care Ultrasound of Quadriceps Muscles

Published on: July 26, 2024

1.5K

Frailty in Clinical Practice.

Matteo Cesari, Bruno Vellas

    Nestle Nutrition Institute Workshop Series
    |October 21, 2015
    PubMed
    Summary
    This summary is machine-generated.

    Frailty, a geriatric syndrome of reduced reserves, presents a clinical challenge due to operationalization controversies. This article addresses these issues and proposes solutions for integrating frailty assessment into clinical practice.

    More Related Videos

    Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
    05:53

    Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty

    Published on: July 24, 2013

    17.2K
    Frailty Assessment in an Aging Mouse Model
    06:58

    Frailty Assessment in an Aging Mouse Model

    Published on: September 23, 2025

    864

    Related Experiment Videos

    Last Updated: Mar 31, 2026

    Author Spotlight: Assessing Surgical Frailty with Point-of-Care Ultrasound of Quadriceps Muscles
    04:00

    Author Spotlight: Assessing Surgical Frailty with Point-of-Care Ultrasound of Quadriceps Muscles

    Published on: July 26, 2024

    1.5K
    Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
    05:53

    Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty

    Published on: July 24, 2013

    17.2K
    Frailty Assessment in an Aging Mouse Model
    06:58

    Frailty Assessment in an Aging Mouse Model

    Published on: September 23, 2025

    864

    Area of Science:

    • Geriatrics
    • Clinical Medicine
    • Aging Research

    Background:

    • Frailty is a geriatric syndrome defined by diminished homeostatic reserves, increasing vulnerability to stressors.
    • Disability in older adults is often irreversible, making frailty a key target for preventive interventions.
    • Despite a well-established theoretical concept, operationalizing frailty for clinical use remains controversial, hindering its integration.

    Purpose of the Study:

    • To discuss the challenges of frailty syndrome in clinical settings.
    • To propose solutions for the operationalization and clinical integration of frailty.
    • To present future research perspectives in the field of frailty.

    Main Methods:

    • Review of existing literature on frailty syndrome.
    • Discussion of clinical experiences from a dedicated frailty clinic.
    • Analysis of current impediments to clinical frailty integration.

    Main Results:

    • Theoretical frailty concept is established, but clinical operationalization faces significant controversy.
    • The lack of standardized operationalization delays frailty's integration into routine clinical practice.
    • A frailty clinic model offers potential solutions and insights.

    Conclusions:

    • Addressing the operationalization of frailty is crucial for its clinical implementation.
    • Implementing frailty interventions can potentially prevent age-related disability.
    • Further research is needed to refine frailty assessment and management strategies.