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Published on: October 14, 2021
Characterization of primary cutaneous CD8+/CD30+ lymphoproliferative disorders
Kathryn J Martires1, Seong Ra, Farah Abdulla
1*Department of Dermatology, New York University School of Medicine, New York, NY; †Department of Dermatology, Kaiser Permanente Los Angeles Medical Center, Los Angeles, CA; ‡San Diego Pathologists Medical Group, Los Angeles, CA; §Department of Dermatology, University of Chicago Pritzker School of Medicine; and ¶Department of Pathology, Southern California Permanente Medical Group, Sunset Medical Center, Los Angeles, CA.
This study investigates rare CD8 positive lymphoproliferative disorders, finding MUM-1 positivity in CD8 LyP and PCALCL cases. MUM-1 may aid in diagnosing these challenging cutaneous lymphomas.
Area of Science:
- Dermatology
- Oncology
- Immunopathology
Background:
- CD30 primary cutaneous lymphoproliferative diseases (PCL) typically involve CD4 positive neoplastic cells.
- Lymphomatoid papulosis (LyP) and primary cutaneous anaplastic large cell lymphoma (PCALCL) are the main types.
- CD8 positive variants present diagnostic challenges, mimicking other cytotoxic lymphomas.
Observation:
- This study reports 7 new cases of CD8 positive LyP and PCALCL.
- A unique case of CD8/CD30 LyP with Type B histology was observed.
- Focal to diffuse MUM-1 positivity was noted in all 7 CD8 cases.
Findings:
- MUM-1 positivity may serve as an auxiliary marker for CD8 positive lymphoproliferative disorders.
- Clinical and histologic features of CD8 LyP and PCALCL resemble their CD4 counterparts.
- Literature review of 106 cases supports similarities between CD8 and CD4 subtypes.
Implications:
- MUM-1 could improve the diagnostic accuracy of CD8 positive cutaneous lymphomas.
- Understanding CD8 variants aids in distinguishing these rare conditions from other cytotoxic lymphomas.
- Further research into CD8 PCL is warranted for optimized patient management.
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