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Related Concept Videos

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
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Skin Tumors Associated With Cutaneous HPV Infection.

Delaney K Sullivan1, Audrey A Shi2, David S Cassarino3

  • 1UCLA-Caltech Medical Scientist Training Program, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.

Journal of Cutaneous Pathology
|October 20, 2025
PubMed
Summary
This summary is machine-generated.

Cutaneous human papillomaviruses (HPVs) are linked to various skin tumors beyond warts. Research is exploring their role in a wider range of epithelial skin lesions and adnexal tumors.

Keywords:
benign tumorscancerhuman papillomavirusskin neoplasms

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Area of Science:

  • Dermatology
  • Oncology
  • Virology

Background:

  • Cutaneous human papillomaviruses (HPVs) are common skin commensals.
  • Mucosal HPV types are known drivers of cancers and papillomas.
  • The role of cutaneous HPVs in skin tumors is less understood.

Purpose of the Study:

  • To review current literature on HPV's association with epithelial skin neoplasms.
  • To integrate epidemiological, molecular, and clinical findings.
  • To identify knowledge gaps regarding HPV and skin tumors.

Main Methods:

  • Literature review synthesizing studies up to 2025.
  • Analysis of HPV presence in various skin neoplasms.
  • Integration of epidemiological, molecular, and clinical data.

Main Results:

  • HPVs are associated with common warts (types 1-4).
  • Beta genus HPVs are linked to epidermodysplasia verruciformis-associated SCC and Bowen disease.
  • Emerging evidence suggests HPV involvement in adnexal tumors like digital papillary adenocarcinoma and sebaceous tumors.

Conclusions:

  • HPV's role in skin tumors is complex and varied.
  • Further research is needed to fully understand HPV's contribution to epithelial skin neoplasms.
  • This review highlights expanding associations of HPV beyond traditional roles.