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Updated: Mar 31, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
Impact of Antibiotic Choice on Pneumonia Readmission Rates
Alice N Hemenway1, Michael A Naretta
11Department of Pharmacy Practice, College of Pharmacy, University of Illinois at Chicago, Rockford, IL; and 2Department of Economics, Michigan State University, East Lansing, MI.
Abstract:
There are many patient and institutional variables associated with a higher risk of rehospitalization within 30 days of an admission for community-acquired pneumonia. However, less is known regarding the impact of antibiotics. A retrospective cohort study of 271 patients was performed to determine whether, when controlling for known factors for readmission, the choice of antibiotic affects 30-day rehospitalization after an index admission of pneumonia. Multivariate logistic regression analysis was performed to determine correlation between antibiotic choice and readmission rates. Empiric tobramycin was associated with a 31.2% increased risk of readmission for any reason (P < 0.01). Empiric and treatment aztreonam were associated with a 13.7% and 13.5% increased risk of readmission with recurrent pneumonia, respectively (both P < 0.05). Further research evaluating these associations is warranted.
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