Related Experiment Video
Updated: Jul 13, 2026
06:01
A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
Published on: August 18, 2015
15.7K
Population-Based in-hospital stroke morbidity and mortality
A J Orencia1, E J Feng2, J P Whisnant3
1From the Department of Health Sciences Research, Mayo Clinic and Mayo Foundation, Rochester, MN, U.S.A.
Summary
In-hospital strokes remained stable, with 42% occurring after procedures. Key mortality factors included age, calendar year, atrial fibrillation, and intracranial hemorrhage, highlighting diverse stroke causes.
Area of Science:
- Neurology
- Epidemiology
- Cardiovascular Medicine
Background:
- In-hospital stroke is a significant concern.
- Understanding its risk and prognostic factors is crucial for patient outcomes.
Purpose of the Study:
- To investigate risk and prognostic factors for in-hospital incident stroke.
- To analyze stroke mortality in hospitalized patients.
Main Methods:
- Surveillance of Rochester, MN residents admitted to the hospital between 1950-1984, excluding those with prior stroke.
- Analysis of stroke attack rates and associated factors.
- Identification of prognostic factors for 30-day stroke mortality.
Main Results:
- In-hospital stroke attack rates were stable across selected years (1970, 1976, 1980).
- 42% of in-hospital strokes were adventitious, often occurring within 2 days of a procedure.
- Nonadventitious strokes were predominantly seen in patients with cardiovascular issues.
- Significant prognostic factors for 30-day mortality included age, calendar year, atrial fibrillation/flutter, and intracranial hemorrhage versus cerebral infarction.
Conclusions:
- In-hospital stroke exhibits heterogeneous pathophysiologic mechanisms.
- Prognostic factors vary, emphasizing the need for tailored management strategies.
- Adventitious strokes post-procedure and nonadventitious strokes in cardiovascular patients represent distinct clinical scenarios.
Related Concept Videos
01:27Regulation of Stroke Volume
The regulation of stroke volume, which is the amount of blood the heart pumps out during each heartbeat, is critical for maintaining a healthy circulatory system. Stroke volume is influenced by three main factors: preload, contractility, and afterload.
Preload refers to the degree of stretch on the heart before it contracts. It's analogous to the stretching of a rubber band; the more it's stretched, the more forcefully it snaps back. This concept is encapsulated in the Frank-Starling law of the...
Preload refers to the degree of stretch on the heart before it contracts. It's analogous to the stretching of a rubber band; the more it's stretched, the more forcefully it snaps back. This concept is encapsulated in the Frank-Starling law of the...
01:29Stroke: Introduction and Types
A stroke is an acute neurological event caused by the sudden disruption of cerebral blood flow, leading to rapid loss of neuronal function. Neurons depend on continuous oxygen and glucose supply, so even brief interruptions can cause irreversible injury within minutes. Strokes are classified into ischemic and hemorrhagic types.Ischemic StrokeIschemic strokes are most common and occur due to arterial occlusion, depriving brain tissue of oxygen and nutrients. This leads to energy failure, ionic...
01:15Ischemic Stroke l: Introduction
Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
01:15Ischemic Stroke ll: Pathophysiology
An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
01:17Hemorrhagic Stroke l: Introduction
A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...
01:29Hemorrhagic Stroke ll: Pathophysiology
A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...