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Updated: Mar 31, 2026

Utilizing Repetitive Transcranial Magnetic Stimulation to Improve Language Function in Stroke Patients with Chronic Non-fluent Aphasia
Published on: July 2, 2013
Contribution of remote cortical dysfunction to the pathogenesis of subcortical aphasia: A (99m)Tc-HMPAO SPECT study
G Demeurisse1, M Verhas1, J Paternot1
1From the Service de Revalidation Neurologique, Hôpital Universitaire Brugmann, Brussels, Belgium.; Service de Diagnostic par Radio-Isotopes, Hôpital Universitaire Brugmann, Brussels, Belgium.
Abstract:
Remote cortical effects of deep-seated lesions were studied by (99m)Tc-hexamethyl-propylenenamine oxime single-photon emission computed tomography at about 50 days after stroke in a population of 16 right-handed aphasic patients. A left-sided regional cortical hypoperfusion was present in all cases. Significant relations were observed between the severity of verbal expression disorders and the degree of regional cortical flow decrease, suggesting that, from a given level of remote dysfunction, the affected cortical areas no longer would be able to play their functional role in language elaboration. There was no difference between the degree of cortical hypoperfusion, whether the morphological lesion was of thromboembolic or hemorrhagic origin.
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