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Updated: Mar 31, 2026

Endothelin-1 Induced Middle Cerebral Artery Occlusion Model for Ischemic Stroke with Laser Doppler Flowmetry Guidance in Rat

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Big-endothelin in acute ischemic stroke.

G F Hamann¹, E Isenberg², M Strittmatter¹

¹From the Department of Neurology, University of Saarland, D-W-6650 Homburg/Saar, Germany.

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association

|October 22, 2015

Summary

This summary is machine-generated.

Elevated big-endothelin (BE) levels in acute ischemic stroke patients correlate with poor outcomes, not stroke location or time. Endothelin may indicate brain tissue damage rather than endothelial dysfunction.

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Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

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Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

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Published on: January 18, 2018

Area of Science:

Neuroscience
Cardiovascular Medicine
Biochemistry

Background:

Acute severe ischemic stroke poses significant health risks.
Endothelin is a potent vasoconstrictor with implications in cerebrovascular diseases.
Understanding biomarkers for stroke prognosis is crucial for patient management.

Purpose of the Study:

To investigate the role of plasma big-endothelin (BE) in patients with acute severe ischemic stroke.
To determine if BE levels correlate with stroke location (supratentorial vs. infratentorial) or patient outcome.

Main Methods:

Plasma big-endothelin (BE) levels were measured in 12 patients with acute severe ischemic stroke.
Patients were categorized based on stroke location (supratentorial vs. infratentorial) and prognosis (good vs. poor).
BE levels were analyzed in relation to stroke characteristics and outcomes.

Main Results:

No significant elevations in BE were observed during the first two weeks post-stroke.
Significant differences in BE levels were not found between supratentorial and infratentorial stroke subgroups (p ≤ 0.07).
Patients with poor outcomes exhibited significantly higher BE levels compared to those with better prognoses (p ≤ 0.05).

Conclusions:

Plasma big-endothelin (BE) levels appear to reflect the extent of damaged cerebral tissue rather than endothelial leakage in ischemic stroke.
Elevated BE may serve as a prognostic indicator for poor outcomes in acute severe ischemic stroke.
Lower endothelin concentrations might be associated with local vasodilation and reperfusion processes.