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Glioblastoma multiforme presenting with recurrent neurological deficits: Transient ischemic attacks or tumor attacks
T Al-Tweigeri1, A Shuaib2, F Denath3
1From the Department of Medicine (Neurology), Saskatoon, Saskatchewan, Canada.
Summary
Transient ischemic attacks (TIAs) may mimic brain tumors. Glioblastoma multiforme can present with TIA-like symptoms, delaying correct diagnosis and treatment. Prompt brain tumor evaluation is crucial for recurrent neurological deficits.
Area of Science:
- Neurology
- Neuro-oncology
- Diagnostic Imaging
Background:
- Transient ischemic attacks (TIAs) are characterized by temporary focal neurological deficits due to disrupted brain blood flow.
- Glioblastoma multiforme (GBM) is an aggressive primary brain tumor.
- Recurrent brief neurological symptoms can be challenging to diagnose.
Purpose of the Study:
- To highlight the importance of considering brain tumors in the differential diagnosis of patients presenting with recurrent TIA-like symptoms.
- To illustrate how GBM can mimic TIAs, leading to diagnostic delays.
- To emphasize the need for thorough investigation in cases of unexplained neurological events.
Main Methods:
- Case series presentation of three patients with glioblastoma multiforme.
- Review of clinical presentations, initial investigations, and diagnostic pathways.
- Confirmation of diagnosis through brain biopsy and advanced imaging.
Main Results:
- Three patients with GBM initially diagnosed with recurrent TIAs were identified.
- The TIA diagnosis persisted for months to two years in these patients.
- Final diagnosis of GBM was established via brain biopsy in two cases and further investigations in one.
Conclusions:
- Glioblastoma multiforme should be included in the differential diagnosis for patients experiencing recurrent transient neurological symptoms.
- Delayed diagnosis of brain tumors can occur when symptoms mimic TIAs.
- Comprehensive diagnostic evaluation is essential for accurate and timely diagnosis of neurological conditions.
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