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Identifying Novel Gene Variants in Coronary Artery Disease and Shared Genes With Several Cardiovascular Risk Factors

Marissa LeBlanc1, Verena Zuber1, Bettina Kulle Andreassen1

  • 1From the Department of Clinical Molecular Biology, Institute of Clinical Medicine, University of Oslo, Oslo, Norway (M.L., B.K.A.); Oslo Centre for Biostatistics and Epidemiology, Department of Biostatistics, University of Oslo, and Research Support Services, Oslo University Hospital, Oslo, Norway (M.L., A.F.); NORMENT - K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway (V.Z., A.W., F.B., Y.W., S.D., O.A.A.); Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway (V.Z., A.W., F.B., S.D., O.A.A.); Oslo Centre for Biostatistics and Epidemiology, Department of Biostatistics, University of Oslo, Oslo, Norway (B.K.A.); Deutsches Herzzentrum München, Technische Universität München, Munich, Germany (L.Z., H.S.); Deutsches Zentrum für Herz-Kreislauf-Forschung, partner site Munich Heart Alliance, Munich, Germany (L.Z., H.S.); Multimodal Imaging Laboratory, University of California at San Diego, La Jolla (Y.W., L.K.M., A.J.S., R.S.D., A.M.D., O.A.A.); Department of Neurosciences, University of California, San Diego, La Jolla, (Y.W., A.M.D.); Department of Radiology, University of California, San Diego, La Jolla (L.K.M., R.S.D., A.M.D.); Department of Psychiatry, University of California, San Diego, La Jolla (W.K.T., A.M.D.); Cognitive Sciences Graduate Program, University of California, San Diego, La Jolla, (A.J.S.); Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway (S.R.); Department of Medical Biochemistry, Lovisenberg Diakonale Hospital, Oslo, Norway (S.R., K.M.G.); Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway (S.R., K.M.G.); Family and Preventive Medicine, Division of Epidemiology, University of California, San Diego, La Jolla (E.B.-C.); Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands (S.L., A.D.); Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom (C.P.N.,

Circulation Research
|October 22, 2015
PubMed

Insights

This study reveals a shared genetic basis between coronary artery disease (CAD) and multiple cardiometabolic risk factors. Discovering novel CAD gene loci advances our understanding of the disease

Area of Science:

  • Genetics
  • Cardiovascular Medicine
  • Metabolic Disorders

Background:

  • Coronary artery disease (CAD) significantly impacts morbidity and mortality.
  • Cardiovascular disease risk factors may share genetic underpinnings with CAD, aiding gene discovery.

Purpose of the Study:

  • To enhance the discovery of CAD genes.
  • To clarify the pathogenic links between CAD and cardiovascular risk factors using a shared polygenic signal-informed framework.

Main Methods:

  • Employed genome-wide association studies summary statistics.
  • Utilized a shared polygenic pleiotropy-informed conditional and conjunctional false discovery rate methodology.
  • Systematically investigated genetic overlap between CAD and eight cardiovascular risk traits.

Main Results:

  • Found significant enrichment of single-nucleotide polymorphisms associated with CAD across multiple risk factors.
  • Identified 67 novel CAD-associated loci using the conditional false discovery rate method.
  • Discovered 53 loci with effects on both CAD and at least one cardiovascular risk factor.

Conclusions:

  • Polygenic overlap between CAD and cardiometabolic risk factors suggests a pathogenic relationship requiring further study.
  • Identified novel gene loci implicating new genetic mechanisms in CAD development.
Abstract

Keywords:
Women’s Genome Health Studycoronary artery diseasecoronary heart diseasegenetic pleiotropygenome-wide association studylipidsmolecular epidemiologymyocardial infarction

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