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Updated: Mar 31, 2026

12:59
Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
Published on: September 26, 2013
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Gut-Busters: IL-17 Ain't Afraid of No IL-23
Natasha Whibley1, Sarah L Gaffen2
1Kennedy Institute of Rheumatology, University of Oxford, Oxford, OX3 7FY, UK.
Immunity
|October 22, 2015
Abstract:
Interleukin-23 (IL-23) is considered a critical regulator of IL-17 in lymphocytes. Whereas antibodies targeting IL-23 ameliorate colitis, IL-17 neutralization exacerbates disease. In this issue, Cua and colleagues and Maxwell and colleagues show that IL-17 maintains intestinal barrier integrity, helping explain this dichotomy (Lee et al., 2015; Maxwell et al., 2015).

