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Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids
Published on: April 25, 2016
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[Simultaneous Analysis of 18 Glucocorticoids in Surface Water]
Huan Jing Ke Xue= Huanjing Kexue
|October 23, 2015
Summary
A new method using ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) can simultaneously detect 18 glucocorticoids in surface water. This technique identified previously undetected glucocorticoids, highlighting its efficiency for environmental monitoring.
Area of Science:
- Environmental Chemistry
- Analytical Chemistry
Context:
- Glucocorticoids are emerging contaminants in surface water.
- Previous analytical methods lacked the sensitivity or scope for comprehensive detection.
Purpose:
- To develop and validate a sensitive method for simultaneous analysis of 18 glucocorticoids in surface water.
- To assess the presence and levels of these compounds in Beijing surface water.
Summary:
- A solid-phase extraction (SPE) coupled with ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method was established for 18 glucocorticoids.
- The method demonstrated good linearity (1.0–1000 µg.L⁻¹), low detection limits (0.10–1.0 ng.L⁻¹), and recoveries (65%–108%).
- Analysis of Beijing surface waters revealed 8 glucocorticoids, including four detected for the first time in this environmental matrix.
Impact:
- This validated UPLC-MS/MS method provides an efficient tool for monitoring glucocorticoid contamination in aquatic environments.
- The findings reveal the widespread occurrence of glucocorticoids and introduce novel analytes in surface water, informing environmental risk assessment.
