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Dynamic cross-flow filtration: enhanced continuous small-scale solid-liquid separation
Johannes Gursch1, Roland Hohl1, Diana Dujmovic1
1a Research Center Pharmaceutical Engineering Graz , Graz , Austria .
Drug Development and Industrial Pharmacy
|October 23, 2015
Summary
This study enhanced small-scale dynamic filtration (SFD) by testing vacuum-enhanced and pulsating modes. These modes significantly increased permeate flow and concentration factors, improving continuous production efficiency.
Area of Science:
- Chemical Engineering
- Separation Processes
- Filtration Technology
Background:
- Previous research characterized basic mechanisms of small-scale dynamic filtration (SFD).
- The current study focuses on enhancing SFD production performance.
Purpose of the Study:
- To improve SFD performance for increased permeate flow and concentration factors (CF).
- To maintain fully continuous production while optimizing operational modes.
Main Methods:
- Testing various operational modes, including vacuum-enhanced and pulsating operations.
- Comparing performance against the standard open-operation mode for filtration.
Main Results:
- Vacuum-enhanced and pulsating modes significantly outperformed the open-operation mode.
- For lactose, CF increased from 1.7 (open mode) to 7.6 (pulsating mode).
- Improved filtration performance and process flexibility were observed.
Conclusions:
- Vacuum-enhanced operation is most promising for industrial integration.
- The tested strategies enable rapid response to fluctuating feed conditions.
- Enhanced SFD operation leads to effective and efficient continuous small-scale filtration.
