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A Mouse Model of Intestinal Partial Obstruction
Published on: March 5, 2018
Mesenteric panniculitis resulting in bowel obstruction: response to steroids
1Department of Surgery, Royal Perth Hospital, Western Australia.
The Australian and New Zealand Journal of Surgery
|March 1, 1989
Summary
Steroid treatment can effectively manage active mesenteric panniculitis (MP), a condition causing bowel obstruction. Early intervention with steroids is crucial, as established fibrosis may render treatment ineffectual.
Area of Science:
- Gastroenterology
- Surgical Pathology
Background:
- Mesenteric panniculitis (MP) is a rare inflammatory condition affecting the mesentery.
- MP can lead to bowel obstruction, necessitating surgical intervention.
Observation:
- Two patients with MP presented with bowel obstruction (sigmoid colon and small bowel).
- Both patients experienced rapid symptomatic improvement following corticosteroid administration.
Findings:
- Active, subacute mesenteric panniculitis, characterized by inflammation and high ESR, responded favorably to steroids.
- Steroid treatment appeared ineffective once significant fibrosis developed in the mesentery.
Implications:
- Early corticosteroid therapy is recommended for active mesenteric panniculitis to prevent disease progression.
- This suggests a potential non-surgical management pathway for early-stage mesenteric panniculitis.
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