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Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
Published on: July 27, 2022
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Comparative study on solid self-nanoemulsifying drug delivery and solid dispersion system for enhanced solubility and
Rehmana Rashid1, Dong Wuk Kim1, Abid Mehmood Yousaf1
1College of Pharmacy and Institute of Pharmaceutical Science and Technology, Hanyang University, Ansan, South Korea.
International Journal of Nanomedicine
|October 23, 2015
Summary
Solvent evaporated solid dispersion (SESD) enhances ezetimibe oral bioavailability by improving solubility and dissolution. SESD is recommended for poorly water-soluble ezetimibe delivery.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
- Formulation Development
Background:
- Ezetimibe exhibits poor water solubility, limiting its oral bioavailability.
- Novel drug delivery systems are crucial for enhancing the efficacy of poorly soluble drugs.
- Solid self-nanoemulsifying drug delivery systems (SNEDDS) and solid dispersions are explored for improved drug delivery.
Purpose of the Study:
- To compare physicochemical properties, solubility, dissolution, and oral bioavailability of ezetimibe-loaded SNEDDS, surface modified solid dispersion (SMSD), and solvent evaporated solid dispersion (SESD).
- To identify the optimal formulation for enhanced oral delivery of ezetimibe.
Main Methods:
- Formulations included liquid SNEDDS converted to solid SNEDDS via spray drying, SMSD, and SESD.
- Characterization involved assessing aqueous solubility, dissolution profiles, particle size, and physicochemical properties.
- Pharmacokinetic studies were conducted to evaluate oral bioavailability.
Main Results:
- SNEDDS and SESD yielded amorphous ezetimibe, while SMSD retained crystalline form.
- All formulations improved solubility and dissolution compared to ezetimibe powder, in the order: solid SNEDDS ≥ SESD > SMSD.
- SESD demonstrated the highest area under the curve, indicating superior oral bioavailability.
Conclusions:
- The solvent evaporated solid dispersion (SESD) system significantly enhances ezetimibe's oral bioavailability.
- SESD is a promising drug delivery system for oral administration of poorly water-soluble ezetimibe.
- Amorphous drug transformation and optimized formulation are key to improved drug delivery.
Keywords:
bioavailabilityezetimibesolid dispersionsolid self-nanoemulsifying drug delivery systemsolubilityMore Related Videos
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