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Human papillomavirus type 2 associated with pyogenic granuloma in patients without clinical evidence of warts

Osvaldo T Vázquez-Martínez1, Anajulia González-Betancourt2, María Carmen Barboza-Cerda3,4

  • 1Servicio de Dermatología, Hospital Universitario "Dr. José E. González", Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, Mexico.

International Journal of Dermatology
|October 23, 2015
PubMed
Abstract

Insights

Human papillomavirus (HPV) DNA was detected in nearly half of pyogenic granuloma samples. This study suggests a potential association between HPV-2 and pyogenic granuloma, similar to its link with nongenital warts.

Area of Science:

  • Dermatology
  • Virology
  • Molecular Biology

Background:

  • Pyogenic granuloma is a common non-neoplastic lesion affecting skin and mucous membranes, particularly in children and pregnant women.
  • The locations of pyogenic granulomas overlap with sites of human papillomavirus (HPV) infections.

Purpose of the Study:

  • To investigate the presence of HPV DNA in pyogenic granuloma lesions using polymerase chain reaction (PCR).

Main Methods:

  • Eighteen pyogenic granuloma biopsies were analyzed for HPV DNA using three independent PCR reactions.
  • Consensus primer sets targeting L1 or E1 regions of the HPV genome were employed.
  • HPV DNA-positive samples were genotyped to identify specific HPV types.

Main Results:

  • HPV DNA was identified in 44.4% (8 out of 18) of the pyogenic granuloma samples.
  • HPV-2 was the sole HPV type detected in all positive samples.
  • Rigorous methods were used to rule out contamination with HPV-2 sequences.

Conclusions:

  • This study provides the first evidence suggesting a link between HPV-2 and pyogenic granuloma.
  • The observed association parallels the known relationship between HPV-2 and nongenital warts.

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