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Updated: Mar 31, 2026
Porcine Liver Transplantation Without Veno-Venous Bypass As an Extended Criteria Donor Model
Published on: August 17, 2022
Current status and perspectives in split liver transplantation
Andrea Lauterio1, Stefano Di Sandro1, Giacomo Concone1
1Andrea Lauterio, Stefano Di Sandro, Giacomo Concone, Riccardo De Carlis, Alessandro Giacomoni, Luciano De Carlis, Transplant Center, Department of General Surgery and Abdominal Transplantation, Niguarda Cà Granda Hospital, Piazza Ospedale Maggiore 3, 20162 Milan, Italy.
Split liver transplantation (SLT) is increasingly used for adult and pediatric recipients, offering results comparable to whole liver transplants. However, SLT for two adult recipients remains challenging, with outcomes needing improvement.
Area of Science:
- Hepatology
- Transplant Surgery
- Surgical Innovation
Background:
- Split liver transplantation (SLT) has gained traction due to favorable outcomes in adult and pediatric recipients.
- Organ shortages and ethical considerations influence the global distribution of SLT.
Purpose of the Study:
- To review surgical and clinical advances in split liver transplantation.
- To focus on the role of SLT and factors influencing its expansion.
Main Methods:
- Review of current literature on SLT techniques and outcomes.
- Analysis of factors contributing to the challenges and successes of SLT.
Main Results:
- SLT shows comparable results to whole liver transplants for single recipients.
- SLT for dual adult recipients presents significant surgical challenges with suboptimal outcomes.
- Technical refinements have improved understanding of liver anatomy for SLT.
Conclusions:
- SLT is a viable option for single recipients, but dual adult recipient transplantation requires further improvement.
- Addressing technical and logistical demands is crucial for expanding SLT.
- Continued advancements are necessary to overcome challenges in this complex procedure.
