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Attention Deficit Hyperactivity Disorder in a Patient With Congenital Mirror Movement Disorder and Colpocephaly
1Bakirkoy Dr. Sadi Konuk Education and Training Hospital, Istanbul, Turkey.
Insights
This case report details a rare association between congenital mirror movements and colpocephaly in an infant. The condition, characterized by involuntary mirroring of hand movements, did not lead to debilitating issues, highlighting the importance of managing associated conditions like ADHD.
Area of Science:
- Neurology
- Developmental Neuroscience
- Pediatric Neurology
Background:
- Congenital mirror movements involve involuntary movements mirroring intentional contralateral actions.
- Colpocephaly is characterized by the persistence of fetal lateral ventricular configuration.
- Both conditions can present in early childhood and have implications for neurological development.
Observation:
- A two-month-old infant presented with bilateral identical hand movements.
- Cranial MRI revealed corpus callosum dysgenesis and colpocephaly.
- The infant was later diagnosed with attention deficit hyperactivity disorder (ADHD) at age seven.
Findings:
- This report describes the first documented association between colpocephaly and congenital mirror movements.
- Mirror movements decreased in severity over time and did not significantly impair the patient's daily activities.
- The co-occurrence of ADHD with mirror movements and/or colpocephaly is also reported for the first time.
Implications:
- Early diagnosis and management of comorbidities, such as ADHD, are crucial for individuals with mirror movements and colpocephaly.
- Understanding the underlying mechanisms of this association may lead to novel therapeutic strategies.
- This case underscores the importance of comprehensive neurological assessment in infants with unexplained movement disorders.
Introduction:
Congenital mirror movement disorder designates involuntary movements on one side of the body that occur as mirror of the intentional movements on the contralateral side. Colpocephaly is described as persistence of fetal configuration of lateral ventricles.
Case Presentation:
A two-month old male infant was brought to the hospital due to bilateral identical movements of the hands. Except for bilateral involuntary synkinetic imitative movements in hands, neurological and physical examination was normal. Cranial MRI showed corpus callosum dysgenesis, hypogenesis and dilation of bilateral lateral ventricular posterior horns (colpocephaly). At the age of 7 years, he was started to use metylphenydate to mitigate attention deficit and hyperactivity disorder. The mirror movements were decreasing in amplitude by years and were not so serious to affect normal life activities.
Conclusions:
Mirror movements, diagnosed usually during childhood, may be congenital or secondary to neurological diseases. Although they generally do not affect normal life activities, in some cases severity of mirror movements causes a real debilitating disease. In our case the patient was diagnosed at the age of 2 months and on follow-up no debilitating problems were observed. This is the first case to describe the association of colpocephaly and mirror movements. The exact mechanism of this association is not known. Although it is known that mirror movements may be in relation with some pychiatric pathologies, this is the first report of attention deficit and hyperactivity disorder in conjunction with mirror movements and/or colpocephaly. Managing comorbidities, either physical or psyhchological, will help the patient to live in good health without trying to cope with other pathological diseases.
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