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Published on: December 23, 2010
Side Effects of Leukotriene Receptor Antagonists in Asthmatic Children
Semiha Bahceci Erdem1, Hikmet Tekin Nacaroglu1, Canan Sule Unsal Karkiner1
1Department of Pediatric Allergy, Dr. Behcet Uz Children's Hospital, Izmir, Turkey.
Background:
Leukotriene receptor antagonists (LTRAs) are drugs which have been widely used more than ten years. As the use of LTRAs increases, our knowledge with respect to their side effects increases as well.
Objectives:
The objective of our study was to evaluat the observed side effects of LTRAs used in patients with astma.
Patients And Methods:
1024 patients treated only with LTRAs owing to asthma or early wheezing were included in the study for a five-year period. The observed side effects of LTRAs in these patients were retrospectively investigated. The side effects were divided into two parts as psychiatric and non-psychiatric.
Results:
Among the 1024 cases included in the study, 67.5% of the patients out of 41 with side effects were male, 32.5% were female and the average age was 6.5 years. The rate of patients with asthma was 63.41% and 36.58% of the patients had early wheezing. It was determined that sex, age and diagnosis (early wheezing or asthma) of the patients were ineffective in the emergence of side effects. The average period for the emergence of side effects was the first month. It was observed that hyperactivity was the most frequently observed psychiatric side effect and that abdominal pain was the non-psychiatric side effect.
Conclusions:
The side effects of LTRAs were common in children. Therefore, patients must be informed at the beginning of the treatment and they must be evaluated at certain intervals.
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