Evolving and investigational therapies for benign prostatic hyperplasia

Area of Science:

• Urology
• Minimally Invasive Surgery

Background:

• Lower urinary tract symptoms (LUTS) are prevalent, frequently linked to benign prostatic hyperplasia (BPH).
• Conventional surgical interventions like open enucleation and transurethral resection of the prostate (TURP) are effective but carry risks and are operator-dependent.
• This review examines novel surgical approaches for BPH management.

Purpose of the Study:

• To review emerging surgical techniques for benign prostatic hyperplasia (BPH).
• To assess the safety and efficacy of new BPH treatment modalities.

Main Methods:

• A systematic literature search was conducted across major databases including SCOPUS, MEDLINE, EMBASE, and Cochrane.
• Keywords related to BPH and surgical techniques were utilized for comprehensive data retrieval.

Main Results:

• Intra-prostatic injections (NX-1207, PRX-302) demonstrate good safety and early efficacy.
• Thermal therapies (Rezum) and Aquablation show promise as outpatient or automated procedures with favorable safety profiles.
• Prostate artery embolization shows variable outcomes, and histotripsy is still in early feasibility stages.

Conclusions:

• Several new BPH techniques exhibit promising safety and efficacy.
• Further validation through phase III studies is required for widespread adoption.