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Differential dopamine function in fibromyalgia.

Daniel S Albrecht1,2,3, Palmer J MacKie4, David A Kareken1,2,3,5

  • 1Department of Radiology & Imaging Sciences, Indiana University School of Medicine, R2 E124, 950 W. Walnut St., Indianapolis, IN, 46202, USA.

Brain Imaging and Behavior
|October 27, 2015
PubMed
Summary
This summary is machine-generated.

Fibromyalgia patients show altered dopamine system function, impacting pain perception and cognitive symptoms. This study reveals lower dopamine D2/D3 receptor availability in FM, correlating with pain severity and sensitivity.

Keywords:
Chronic painDopamineFallyprideFibromyalgiaImagingPainPositron emission tomography

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Area of Science:

  • Neuroscience
  • Pain Research
  • Radiology

Background:

  • Chronic pain, including fibromyalgia (FM), affects millions, often inadequately treated by existing drugs.
  • Current treatments lack efficacy for pain and cognitive symptoms, with high addiction potential.
  • Neurobiological underpinnings of chronic pain are unclear, but dopamine system alterations are implicated.

Purpose of the Study:

  • To investigate the dopamine (DA) system in individuals with fibromyalgia.
  • To assess DA changes during cognitive tasks and their relation to pain perception.
  • To explore the link between dopamine D2/D3 receptor availability and pain measures in FM.

Main Methods:

  • Positron emission tomography (PET) using [(18)F]fallypride (FAL) was employed.
  • DA system function was assessed during working memory (2-back) and baseline (0-back) tasks.
  • Associations between baseline D2/D3 availability and pain sensitivity/tolerance were examined.

Main Results:

  • Fibromyalgia subjects exhibited lower baseline FAL binding potential (BP) in cortical regions, including the anterior cingulate cortex, compared to controls.
  • In FM patients, spontaneous pain negatively correlated with FAL BP in the orbitofrontal cortex and parahippocampal gyrus.
  • Baseline D2/D3 availability negatively correlated with pain sensitivity and tolerance in both FM and control groups, with group-specific spatial patterns.

Conclusions:

  • Abnormal dopamine function appears linked to altered pain processing in fibromyalgia.
  • Dopamine system dysregulation may contribute to both pain and cognitive deficits in chronic pain conditions.
  • Further research is warranted to elucidate the role of dopamine in nociception and cognition within chronic pain.