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Related Concept Videos

Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

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Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial...
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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Hypersensitivity Reactions: Cytolytic Reactions01:01

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Type II hypersensitivity involves IgG and IgM antibodies targeting cell surface antigens, leading to cell destruction. This can occur through complement activation, antibody-dependent cell-mediated cytotoxicity (ADCC), or acting as opsonins for phagocytosis. When excessive, these reactions cause significant tissue damage.Drug-induced hemolytic anemia is a common example, where drugs like penicillin or cephalosporins bind to red blood cells, forming drug-protein complexes. These complexes...
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Acne Infection01:27

Acne Infection

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Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
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Papillary Dermis01:11

Papillary Dermis

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Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
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The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
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Cutaneous Eruption due to Telaprevir.

Eduardo Mastrangelo Marinho Falcão1, Beatriz Moritz Trope1, Mariana Marteleto Godinho1

  • 1Sector of Dermatology and Post-Graduation Course, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

Case Reports in Dermatology
|October 27, 2015
PubMed
Summary

Hepatitis C treatment with telaprevir can cause severe skin reactions. Early recognition and management of these adverse skin events are crucial for patient care.

Keywords:
Drug eruptionHepatitis CTelaprevir

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Area of Science:

  • Hepatology
  • Dermatology
  • Virology

Background:

  • Hepatitis C virus (HCV) infection affects 0.5-3% globally, often leading to cirrhosis.
  • Direct-acting antivirals like telaprevir have improved HCV treatment outcomes since 2011.
  • Skin eruption is a notable side effect associated with these antiviral therapies.

Observation:

  • A 53-year-old patient with HCV-induced cirrhosis was treated with telaprevir.
  • The patient developed a severe skin rash in the ninth week of treatment.
  • The adverse skin reaction necessitated the discontinuation of telaprevir therapy.

Findings:

  • Telaprevir, a key drug in modern Hepatitis C treatment, is associated with significant dermatological side effects.
  • Severe cutaneous adverse reactions can occur during antiviral therapy for HCV.
  • Prompt identification of skin issues is vital for managing treatment complications.

Implications:

  • Clinicians must be vigilant for skin reactions in patients undergoing HCV treatment with telaprevir.
  • Management strategies for drug-induced skin eruptions are essential for patient safety.
  • Understanding and mitigating side effects can improve the overall efficacy and tolerability of Hepatitis C therapies.