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Updated: Mar 31, 2026

Analyzing Tumor and Tissue Distribution of Target Antigen Specific Therapeutic Antibody
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Therapeutic Monoclonal Antibodies and Fragments: Ranibizumab

Adiel G Smith, Peter K Kaiser

    Developments in Ophthalmology
    |October 27, 2015
    PubMed

    Ranibizumab is a recombinant, humanized, affinity-matured, monoclonal antibody Fab fragment against all isoforms of vascular endothelial growth factor-A, which was developed specifically for intraocular use. Ranibizumab has been extensively investigated in clinical trials on choroidal neovascularization from wet age-related macular degeneration and pathologic myopia, as well as macular edema due to diabetic retinopathy and retinal vein occlusion. Numerous randomized, controlled clinical trials have shown this medication to be effective in improving both vision as well as anatomical outcomes, and the medication has repeatedly shown to have an acceptable safety profile.

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