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Motion correction in simultaneous PET/MR brain imaging using sparsely sampled MR navigators: a clinically feasible

Sune H Keller1, Casper Hansen2, Christian Hansen3

  • 13982 Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, DK-2100, Copenhagen, Denmark. sune@pet.rh.dk.

EJNMMI Physics
|October 27, 2015
PubMed
Summary

Motion correction (MC) using MR navigators during simultaneous PET/MR brain scans improved image quality and reduced blurring. This method is feasible for clinical use, enhancing diagnostic accuracy for brain imaging studies.

Keywords:
Clinical toolsMotion correctionMotion quality controlNavigatorsPET/MRRigid head motion

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Area of Science:

  • Neuroimaging
  • Medical Physics

Background:

  • Simultaneous PET/MR imaging offers combined functional and anatomical data for brain studies.
  • Head motion during PET/MR scans can significantly degrade image quality and affect diagnostic accuracy.
  • Developing effective motion correction techniques is crucial for maximizing the clinical utility of PET/MR.

Purpose of the Study:

  • To evaluate the clinical feasibility of motion correction (MC) for PET imaging during simultaneous PET/MR brain scans.
  • To assess the potential improvement in PET image quality using MR navigators for motion correction.
  • To investigate the impact of MC on the interpretation of PET/MR brain scans.

Main Methods:

  • Utilized 3D MR navigators sampled between MR sequences during simultaneous PET/MR brain scans.
  • Applied motion correction to PET data from 29 subjects undergoing [(11)C]-PiB PET scans.
  • Reconstructed PET images in multiple frames for subjects with significant motion (>4 mm) before averaging post-MC.

Main Results:

  • Head motion up to 11 mm was observed, with an average maximum motion of 3.9 mm.
  • Visual assessment showed a reduction in blurring in PET images after motion correction.
  • Image quality scores improved from an average of 3.4 to 4.0 post-MC, indicating better image clarity.

Conclusions:

  • Sparsely sampled MR navigators are effective for characterizing and correcting head motion in PET/MR brain imaging.
  • Motion correction resulted in a slight decrease in blurring and improved image quality without altering clinical interpretation.
  • This method provides a simple and valuable tool for motion correction in future PET/MR studies, particularly those with significant motion artifacts.