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Nerve Ultrasound Protocol to Detect Dysimmune Neuropathies

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Published on: October 7, 2021

Neuropathies in Systemic Disease.

Michael P Bowley¹, Allan H Ropper²

¹Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts.

Seminars in Neurology

|October 28, 2015

Summary

This summary is machine-generated.

Peripheral neuropathies often stem from systemic diseases. This review covers clinical, electrographic, and histopathological features of neuropathies linked to kidney failure, GI illness, thyroid issues, and infections.

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Area of Science:

Neurology
Systemic Diseases
Peripheral Nervous System Disorders

Background:

Peripheral neuropathies are frequently secondary to underlying systemic conditions.
Understanding the pathophysiology of these neuropathies is crucial for effective management.
A comprehensive review of various systemic diseases causing peripheral neuropathy is warranted.

Purpose of the Study:

To review the clinical features, electrophysiologic abnormalities, histopathological findings, and treatment of peripheral neuropathies associated with systemic diseases.
To highlight the current understanding of pathophysiological mechanisms in these conditions.
To emphasize specific peripheral neuropathic manifestations in renal failure, gastrointestinal illness, bariatric surgery, thyroid dysfunction, connective tissue disease, infections, and critical illness.

Main Methods:

Literature review focusing on peripheral neuropathies and systemic diseases.
Synthesis of information regarding clinical presentation, diagnostic findings, and therapeutic approaches.
Emphasis on pathophysiological insights and disease-specific manifestations.

Main Results:

Peripheral neuropathies manifest diversely depending on the underlying systemic disease.
Key features include specific clinical signs, electrodiagnostic patterns, and histopathological changes.
Pathophysiological mechanisms, while incompletely understood, involve various pathways related to systemic dysfunction.

Conclusions:

Systemic diseases are the primary cause of most peripheral neuropathies.
Early recognition and understanding of disease-specific neuropathic features are vital for diagnosis and treatment.
Further research into pathophysiological mechanisms is needed to improve therapeutic strategies for peripheral neuropathies.