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Updated: Mar 31, 2026

Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291
Published on: December 10, 2016
Cadazolid Does Not Promote Intestinal Colonization of Vancomycin-Resistant Enterococci in Mice
Peter Seiler1, Michel Enderlin-Paput2, Philippe Pfaff2
1Actelion Pharmaceuticals Ltd., Allschwil, Switzerland peter.seiler@actelion.com.
Abstract:
The promotion of colonization with vancomycin-resistant enterococci (VRE) is one potential side effect during treatment of Clostridium difficile-associated diarrhea (CDAD), resulting from disturbances in gut microbiota. Cadazolid (CDZ) is an investigational antibiotic with potent in vitro activity against C. difficile and against VRE and is currently in clinical development for the treatment of CDAD. We report that CDZ treatment did not lead to intestinal VRE overgrowth in mice.
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