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Updated: Mar 31, 2026
Quantifying Synapses: an Immunocytochemistry-based Assay to Quantify Synapse Number
Published on: November 16, 2010
Quantitative analysis of mouse corpus callosum from electron microscopy images
Kathryn L West1, Nathaniel D Kelm1, Robert P Carson2
1Department of Biomedical Engineering, Vanderbilt University, United States ; Vanderbilt University Institute of Imaging Science, Vanderbilt University, United States.
Abstract:
This article provides morphometric analysis of 72 electron microscopy images from control (n=4) and hypomyelinated (n=2) mouse corpus callosum. Measures of axon diameter and g-ratio were tabulated across all brains from two regions of the corpus callosum and a non-linear relationship between axon diameter and g-ratio was observed. These data are related to the accompanying research article comparing multiple methods of measuring g-ratio entitled 'A revised model for estimating g-ratio from MRI' (West et al., NeuroImage, 2015).
