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Updated: Mar 31, 2026

Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds
Published on: October 29, 2015
A novel isocoumarin with anti-influenza virus activity from Strobilanthes cusia
Wei Gu1, Wei Wang2, Xiao-Nian Li3
1The Key Laboratory of Chemistry fro Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550002, Guizhou, People's Republic of China.
Abstract:
Strobilanthes A (1), a novel isocoumarin with an unusual tetrahydro-4H-pyran-4-one moiety fused isocoumarin core skeleton, together with a known compound (2) was isolated from Strobilanthes cusia. Its chemical structures were elucidated by 2D NMR spectroscopy, mass spectrometry and single-crystal X-ray diffraction analysis. The biosynthetic pathway of 1 could be supposed to be originally derived from 3-methylisocoumarin, a product of AA-MA pathway. Both of two compounds displayed anti-influenza virus activity in vitro.
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