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Bioactivity-guided isolation of new antiproliferative compounds from Juniperus foetidissima Willd
Mahmood Rafieian-Kopaei1, Ibrahim Suleimani Dehkordi2, Mustafa Ghanadian3,4
1a Department of Pharmacology , Shahrekord University of Medical Sciences , Shahrekord , Iran.
Abstract:
Based on a literature survey on cytotoxic medicinal plants, Juniper species were identified as interesting source of antitumor compounds. Using bioassay-guided fractionation against Caov-4 cancer cells on acetone extract of leaves and branchlets of Juniperus foetidissima led to the isolation of a new 3H-benzofuaran-2-one: 4-methyl-3-methoxy-3H-benzofuaran-2-one (1), a new sesquiterpene: 4,9(α)-dihydroxy-nardosin-6-en (2) and an already known labdane-type diterpene: 15-hydroxy-8(17),13(E)-labdadiene-19-carboxilic acid (3). Compounds 1-3 exhibited cytotoxic effects, with moderate cytotoxicity against the EJ-138 bladder and CAOV-4 ovary cancer cell lines.
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