Related Experiment Video

Updated: Mar 31, 2026

Author Spotlight: Establishment and Confirmation of a Postnatal Right Ventricular Volume Overload Mouse Model
06:04

Author Spotlight: Establishment and Confirmation of a Postnatal Right Ventricular Volume Overload Mouse Model

Published on: June 9, 2023

1.6K

Cardiac Mechanics in Children with Bronchopulmonary Dysplasia

Lijian Xie1, Yuet-Yee Chee, Kar-Yin Wong

  • 1Shanghai Children's Hospital, Shanghai Jiaotong University, Shanghai, SAR, China.

Neonatology
|October 28, 2015
PubMed

Insights

Cardiac mechanics are altered in premature infants with bronchopulmonary dysplasia (BPD). Impaired right ventricular (RV) myocardial deformation in BPD is linked to the duration of invasive ventilation.

Area of Science:

  • Pediatric Cardiology
  • Neonatology
  • Pulmonary Medicine

Background:

  • Bronchopulmonary dysplasia (BPD) involves disrupted pulmonary vasculogenesis, potentially impacting ventricular mechanics due to increased pulmonary flow impedance.
  • Altered cardiac function may be a consequence of abnormal vascular development in BPD.

Purpose of the Study:

  • To investigate whether cardiac mechanics are altered in prematurely born children diagnosed with BPD.
  • To test the hypothesis linking BPD to changes in ventricular function.

Main Methods:

  • A cohort of 47 children was studied, categorized into three groups: preterm with BPD (n=22), preterm without BPD (n=13), and healthy term-born controls (n=12).
  • Speckle-tracking echocardiography was employed to assess left ventricular (LV) and right ventricular (RV) strain and strain rate.

Main Results:

  • Children with BPD exhibited significantly lower global RV systolic strain rate and tended to have lower RV systolic strain and early diastolic strain rate compared to controls.
  • LV longitudinal systolic strain rate also tended to be lower in the BPD group. LV size was significantly smaller in the BPD group.
  • Duration of invasive ventilation independently predicted RV systolic strain, indicating a negative association.

Conclusions:

  • Children with BPD demonstrate impaired RV myocardial deformation.
  • The degree of RV myocardial impairment in BPD is inversely associated with the duration of invasive ventilation received.
Abstract

More Related Videos

Hemodynamic Precision in the Neonatal Intensive Care Unit using Targeted Neonatal Echocardiography09:31

Hemodynamic Precision in the Neonatal Intensive Care Unit using Targeted Neonatal Echocardiography

Published on: January 27, 2023

1.8K
Author Spotlight: Simulating Pediatric Cardiac Surgery Using a Neonatal Piglet Model04:55

Author Spotlight: Simulating Pediatric Cardiac Surgery Using a Neonatal Piglet Model

Published on: May 26, 2023

1.5K

Related Concept Videos

Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
757
Pulmonary Cycle: Exhalation01:17

Pulmonary Cycle: Exhalation

In terms of human respiration, the act of expelling air, known as exhalation (or expiration), operates on the principle of pressure gradients. During expiration, the pressure within the lungs exceeds that of the surrounding atmosphere. Under normal conditions, quiet breathing involves passive exhalation and is free of muscular contractions. This is because the exhalation process is driven by the natural elastic recoil of the lungs and chest wall, both of which have an inherent tendency to...
4.9K
Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
1.3K
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
708
Pathophysiology of Cardiac Performance01:29

Pathophysiology of Cardiac Performance

Typical heart performance is influenced by heart rate, rhythm, myocardial contraction, and metabolism or blood flow. The cardiac muscle exhibits distinct electrophysiological features, including pacemaker activity and calcium channel control, which play a vital role in the heart's response to various drugs. The autonomic nervous system, comprising the sympathetic and parasympathetic branches, regulates heart rate. Sympathetic activation increases heart rate, while parasympathetic activation...
2.0K
Imbalances in Cardiac Output01:26

Imbalances in Cardiac Output

The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
3.4K