Related Experiment Video

Updated: Aug 16, 2026

Murine Echocardiography of Left Atrium, Aorta, and Pulmonary Artery
08:17

Murine Echocardiography of Left Atrium, Aorta, and Pulmonary Artery

Published on: February 20, 2017

15.2K

The Association Between Baseline Left Atrial Volume Index and All-Cause Mortality in Patients with Heart Failure: A

Bhavadharini Ramu, Ahmed M Elwan, Craig I Coleman

    Connecticut Medicine
    |October 29, 2015
    PubMed

    Insights

    Left atrial volume index (LAVI) is a significant predictor of mortality in heart failure (HF) patients. Each 10 mL/m2 increase in baseline LAVI correlates with a 22% higher risk of all-cause mortality.

    Area of Science:

    • Cardiology
    • Echocardiography
    • Prognostic Biomarkers

    Background:

    • Left atrial enlargement is a known mortality risk factor in the general population.
    • Left atrial volume index (LAVI) is a proposed prognostic measure for heart failure (HF).

    Purpose of the Study:

    • To evaluate baseline LAVI as an independent predictor of all-cause mortality in HF patients.
    • To synthesize evidence from existing studies on the prognostic value of LAVI in heart failure.

    Main Methods:

    • Systematic meta-analysis of four studies identified via Medline and Embase.
    • Inclusion criteria: HF cohorts, multivariate analysis of LAVI and mortality, reported data on LAVI (mL/m2) and all-cause mortality.
    • Pooled adjusted hazard ratios using random-effects meta-analysis.

    Main Results:

    • A 10 mL/m2 increase in baseline LAVI was associated with a 22% increased adjusted hazard of all-cause mortality.
    • Confidence interval for this association was 13% to 31% (I2 = 14%).

    Conclusions:

    • Baseline LAVI is a crucial independent predictor of all-cause mortality in heart failure.
    • Routine reporting of LAVI in echocardiography for HF patients is recommended.
    Abstract

    More Related Videos

    Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation08:10

    Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation

    Published on: July 20, 2022

    2.2K
    Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure05:16

    Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure

    Published on: June 10, 2025

    773

    Related Concept Videos

    Pathophysiology of Heart Failure01:17

    Pathophysiology of Heart Failure

    Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
    Mitral Regurgitation I: Introduction01:20

    Mitral Regurgitation I: Introduction

    Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
    Mitral Stenosis I: Introduction01:22

    Mitral Stenosis I: Introduction

    Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
    Heart Failure I: Introduction01:27

    Heart Failure I: Introduction

    Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
    Heart Failure II: Pathophysiology01:29

    Heart Failure II: Pathophysiology

    Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
    Heart Failure III: Clinical Manifestations01:26

    Heart Failure III: Clinical Manifestations

    Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...