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Updated: Mar 31, 2026

Normothermic Negative Pressure Ventilation Ex Situ Lung Perfusion: Evaluation of Lung Function and Metabolism
Published on: February 14, 2022
Lung protective ventilation and hospital survival of cardiac intensive care patients
M Schneck1, K Holder2, S Gielen2
1Department of Medicine III, University Hospital of Halle, Martin-Luther University Halle-Wittenberg, Ernst-Grube-Str. 40, 06097, Halle, Germany. Michael.Schneck@uk-halle.de.
Objective:
To detect connections between parameters of ventilation and outcomes of cardiac intensive care patients.
Design And Setting:
Noninterventional study. Between 05/11 and 05/12 all patients with acute heart failure and post cardiopulmonary resuscitation were registered. Lung protective ventilation was defined as peak inspiratory pressure (PIP) < 30 mmHg and tidal volume (Vt) < = 6 ml/kg.
Results:
In total, 129 patients were included in the study, 68.2 % male, age 67.9 ± 13.4 years, weight 71.4 ± 37.2 kg, predictive body weight 66.9 ± 8.8 kg, mortality 47.3 %. Lung protective ventilated patients at day 1: 17.3 % with a significant difference between surviving and nonsurviving patients (24.1 % vs. 9.6 %; p < 0.05). Logistic regression models showed a strong connection between PIP and survival (odds ratio 1.13; p < 0.05). Vt showed no significant influence on survival.
Conclusion:
Our data recommends a strict observance of a low PIP for cardiac intensive care patients, whereas Vt seems to be of secondary importance.
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